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In a thru-axle system, the dropouts have closed-off circular openings, rather than an open end. That means there's no risk of the wheel falling out as you ride. The thru-axle passes through the dropout on one side of the wheel and screws into threads in the dropout on the other side.
As well as being more secure, you can exert more clamping force on a thru-axle for a more rigid interface between the wheel and the frame.
One result of that more rigid connection is that bike makers have been able to build frames lighter, helping to bring the weight of disc brake bikes down to a level comparable with rim brake bikes.